### A Maximum-Likelihood Procedure for Clusters with a Known Probability Distribution

Brian P. M. Morris, Zachary H. Levine

Published April 25, 2016

We present an implementation of the Poisson-Influenced -Means Algorithm (PIKA), first developed to characterize the output of a superconducting transition edge sensor (TES) in the few-photon-counting regime. The algorithm seeks to group data into several clusters that minimize their distances from their means, as in classical -means clustering, but with the added knowledge that the cluster sizes should follow a Poisson distribution. Read More »

Javad Abdalkhani

Published February 27, 2016

Picard’s iteration is used to find the analytical solutions of some Abel–Volterra equations. For many equations, the integrals involved in Picard’s iteration cannot be evaluated. The author approximates the solutions of those equations employing a semi-implicit product midpoint rule.The Aitken extrapolation is used to accelerate the convergence of both methods. A blow-up phenomena model, a wave propagation, and a superfluity equation are solved to show the practicality of the methods. Programs offered solve the general equations. A user needs only to enter the particular forcing and kernel functions, constants, and a step size for a particular problem. Read More »

### Designing siRNAs for Gene Silencing

Todd D. Allen

Published January 29, 2016

Biological systems possess traits that are a product of coordinated gene expression, heavily influenced by environmental pressures. This is true of both desirable and undesirable traits (i.e. disease). In cases of unwanted traits, it would be tremendously useful to have a means of systematically lowering the expression of genes implicated in producing the undesirable traits. This article describes the implementation of a computational biology algorithm designed to compute small interfering RNA sequences, capable of systematically silencing the expression of specific genes. Read More »